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January 1, 1995

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Dr Inoue concludes that loose stools are a significant risk factor for colon cancer.

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Subsite-specific risk factors for colorectal cancer: a hospital-based case-control study in Japan.

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Dr M Inoue, et al published in 1995 an investigation of cancers at several colorectal subsites: ascending, transverse, descending, sigmoid, andrectum, within a Japanese hospital environment. They concluded that loose or soft faeces are a significant risk factor for cancer at these sites.

Abstract

To investigate the subsite-specific risk factors for colorectal cancer, we conducted a case-control study, using a common questionnaire which inquired about general lifestyles over the past five years (1988-92), at the Aichi Cancer Center Hospital, Nagoya, Japan. This study compared 432 patients with histopathologically diagnosed colorectal cancer (94 proximal colon [cecum, ascending colon, transverse colon]; 137 distal colon [descending colon, sigmoid colon]; 201 rectum [rectosigmoid, rectum]); and 31,782 first-visit outpatient controls who were free from cancer. In both genders, habitual smoking selectively increased the risk for rectum cancer. Soft or loose feces increased the risk for all subsites of colorectal cancer, particularly in female rectum cancer (odds ratio [OR] = 4.5). Among female dietary habits, Japanese-style foods decreased the risk for distal colon cancer, but increased the risk for proximal colon cancer. These results suggested that the risk factors for colorectal cancer differ by subsite among such a low-risk population as the Japanese. It is suggested also that 'irritable bowel' (soft or loose feces) might be associated with distal subsites of colorectal cancer, independently or combined with habitual smoking.

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Cancer
Cancer is a metabolic disease where the mitochrondria are no longer able to burn fatty acids and instead rely on fermentation of glucose and glutamine. Ketogenic diets have been used to prevent and cure cancer, as they induce a metabolic stress on cancer cells who cannot use ketones as fuel.
Digestion
Digestion is the process by which the body breaks down food into smaller components that can be absorbed and utilized for energy, growth, and repair. It involves both mechanical and chemical processes that occur in various organs of the digestive system.
Fiber
Fiber, also known as dietary fiber or roughage, refers to the indigestible portion of plant foods. It is a type of carbohydrate that cannot be broken down by human digestive enzymes. Instead, it passes through the digestive system relatively intact, adding bulk to the stool and aiding in the regularity of bowel movements. It isn't technically classified as an essential nutrient. The term "essential" in nutrition refers to nutrients that the body cannot produce on its own (or cannot produce in sufficient quantities) and therefore must obtain from the diet
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