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A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome

Cox J; Williams S; Grove K; Lane RH; Aagaard-Tillery KM; Cox, James; Williams, Sarah; Grove, Kevin; Lane, Robert H; Aagaard-Tillery, Kjersti M

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Objective: To characterize the serum metabolome of a primate model of in utero high-fat exposure.Study Design: Serum from maternal and fetal (e130) macaque monkeys exposed to either a high-fat or control diet were analyzed by gas chromatography-mass spectrometry. Multivariate data analysis was performed to reduce the generated data set. Candidate metabolites were further analyzed for significance by using the analysis of variance and comparative t tests.Results: Approximately 1300 chromatographic features were detected. Through multivariate data analysis this number was reduced to 60 possible metabolites. With the use of comparative t tests, 22 metabolites had statistical significance (P < .05) over the entire study. By virtue of maternal high-fat diet alone, fetal phenotypic differences are accompanied by altered metabolite concentrations of 7 metabolites (P

Automatic Tags

Primates; Multivariate Analysis; Genes; Fetal Development; Mass Spectrometry; Animal Studies; Dietary Fats -- Administration and Dosage; Fetus -- Metabolism; Metabolism -- Physiology

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