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The effects of a low-sodium base-producing diet including red meat compared with a high-carbohydrate, low-fat diet on bone turnover markers in women aged 45-75 years

Nowson, Caryl A.; Patchett, Annabelle; Wattanapenpaiboon, Naiyana

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PMID: 19445819


A randomised, parallel-design dietary intervention study was conducted in women (aged 45-75 years) with prehypertension or stage 1 hypertension. The aim was to compare the effects on bone turnover of a low-Na base-producing (LNAB) Dietary Approaches to Stop Hypertension (DASH)-type diet (including six serves lean red meat/week) with a high-carbohydrate low-fat (HCLF) diet with a higher acid load (both >800 mg dietary Ca/d). Fasting serum bone markers (baseline and week 14) and 24 h urinary electrolyte excretion (baseline, weeks 4, 8, 12 and 14) were measured. After the intervention period, the LNAB group (n 46) had a fall of 26 (sem 6) % (P < 0.0001) in urinary Na, an increase in K excretion (6.8 (sem 3.6) mmol/d; P = 0.07) and, compared with the HCLF group (n 49), a greater reduction in urinary Ca excretion by 0.7 (sem 0.3) mmol/d. Serum 25-hydroxyvitamin D, intact parathyroid hormone and osteocalcin did not change, and both groups had a similar increase of 23 (sem 5) % (P

Automatic Tags

Female; Humans; Bone Remodeling; Aged; Middle Aged; Diet, Fat-Restricted; Diet; Biomarkers; Dietary Carbohydrates; Blood Pressure; Calcium; Hypertension; Body Weight; Sodium; Potassium; Meat; Acid-Base Equilibrium; Diet, Sodium-Restricted; Bone Resorption

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