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Comparing metabolite profiles of habitual diet in serum and urine

Playdon, Mary C.; Sampson, Joshua N.; Cross, Amanda J.; Sinha, Rashmi; Guertin, Kristin A.; Moy, Kristin A.; Rothman, Nathaniel; Irwin, Melinda L.; Mayne, Susan T.; Stolzenberg-Solomon, Rachael; Moore, Steven C.

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Background: Diet plays an important role in chronic disease etiology, but some diet-disease associations remain inconclusive because of methodologic limitations in dietary assessment. Metabolomics is a novel method for identifying objective dietary biomarkers, although it is unclear what dietary information is captured from metabolites found in serum compared with urine. Objective: We compared metabolite profiles of habitual diet measured from serum with those measured from urine. Design: We first estimated correlations between consumption of 56 foods, beverages, and supplements assessed by a food-frequency questionnaire, with 676 serum and 848 urine metabolites identified by untargeted liquid chromatography mass spectrometry, ultra-high performance liquid chromatography tandem mass spectrometry, and gas chromatography mass spectrometry in a colon adenoma case-control study (n = 125 cases and 128 controls) while adjusting for age, sex, smoking, fasting, case-control status, body mass index, physical activity, education, and caloric intake. We controlled for multiple comparisons with the use of a false discovery rate of

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Female; Male; Adult; Aged; Body Mass Index; Energy Intake; Diet; Dietary Supplements; Nutritional Status; Chromatography, High Pressure Liquid; Socioeconomic Factors; Fasting; Food; Smoking; Human; Vitamins; Metabolomics; Self Report; Gas Chromatography-Mass Spectrometry; Colonic Neoplasms; Food Intake; Middle Age; Questionnaires; Serum; Urinalysis; Data Analysis Software; Funding Source; Physical Activity; Urine; Nutritional Assessment; Analysis of Covariance; Chi Square Test; T-Tests; Adolescence; Biomarker; Urine -- Metabolism; Logistic Regression; Pearson's Correlation Coefficient; Fisher's Exact Test; Metabolite; Nutrition assessment; Chronic Disease -- Risk Factors; Cancer Patients; Case Control Studies; Wilcoxon Signed Rank Test; Biological Markers -- Metabolism; Blood -- Metabolism; *diet; *food; *metabolite; *metabolomics; *nutrition assessment; *serum; *urine; Food and Beverages; Hospitals, Military; Maryland; MyPlate

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