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Association Between Use of Multiple Classes of Antibiotic in Infancy and Allergic Disease in Childhood

Zven, Sidney E.; Susi, Apryl; Mitre, Edward; Nylund, Cade M.

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December 20, 2019

10.1001/jamapediatrics.2019.4794

Abstract:

Antibiotic administration negatively affects the microbiome by decreasing bacterial diversity, and this has been associated with allergic disease. Exposure to multiple classes of antibiotics may lead to even greater perturbations to the gut biome than 1 class alone. The purpose of this study is to determine whether exposure to multiple antibiotic classes in infancy is associated with a higher risk of developing allergic disease in early childhood.

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