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Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial

Thomsen, Mads N.; Skytte, Mads J.; Samkani, Amirsalar; Carl, Martin H.; Weber, Philip; Astrup, Arne; Chabanova, Elizaveta; Fenger, Mogens; Frystyk, Jan; Hartmann, Bolette; Holst, Jens J.; Larsen, Thomas M.; Madsbad, Sten; Magkos, Faidon; Thomsen, Henrik S.; Haugaard, Steen B.; Krarup, Thure

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January 7, 2022

10.1007/s00125-021-05628-8

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Abstract:

Lifestyle modification and weight loss are cornerstones of type 2 diabetes management. However, carbohydrate restriction may have weight-independent beneficial effects on glycaemic control. This has been difficult to demonstrate because low-carbohydrate diets readily decrease body weight. We hypothesised that carbohydrate restriction enhances the beneficial metabolic effects of weight loss in type 2 diabetes.