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Heated palm oil causes rise in blood pressure and cardiac changes in heart muscle in experimental rats

Leong, Xin Fang; Aishah, A.; Nor Aini, U.; Das, Srijit; Jaarin, Kamsiah

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2008-08

10.1016/j.arcmed.2008.04.009

PMID: 18662587

Abstract:

BACKGROUND: Palm oil used worldwide contains considerable amounts of antioxidants, namely, vitamin E and carotenes. The purpose of the study was to observe the effect of heated palm oil on blood pressure and observe the cardiac histological changes in rats. METHODS: Forty male Sprague Dawley rats were divided equally into four groups and given treatment as follows: (i) basal diet (control group); (ii) basal diet fortified with 15% weight/weight (w/w) fresh palm oil (FPO); (iii) basal diet fortified with 15% w/w palm oil heated five times (5HPO); (iv) basal diet fortified with 15% w/w palm oil heated ten times (10HPO). Treatment duration was 16 weeks. Blood pressure was measured at baseline and at monthly intervals for 4 months using the tail-cuff method. After 16 weeks of study, the rats were killed and the hearts were taken out. The specimens were sectioned longitudinally and stained with hematoxylin and eosin for light microscopy. RESULTS: The FPO group did not show any significant changes in blood pressure and histological study. There was a significant increase (p

Automatic Tags

Animals; Male; Organ Size; Plant Oils; Hot Temperature; Blood Pressure; Body Weight; Palm Oil; Rats; Heart; Rats, Sprague-Dawley; Myocardium

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