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Ketone body metabolism in failing heart

Monzo, Luca; Sedlacek, Kamil; Hromanikova, Katarina; Tomanova, Lucie; Borlaug, Barry A.; Jabor, Antonin; Kautzner, Josef; Melenovsky, Vojtech

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November 25, 2020

10.1016/j.metabol.2020.154452

PMID: 33248064

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Abstract:

AIMS: Upregulation of ketone body (β-hydroxybutyrate, βHB) utilization has been documented in human end-stage heart failure (HF), but is unclear if this is due to intrinsic cardiac metabolic remodeling or a HF-related catabolic state. This study sought to evaluate the maximal ketone body utilization capacity and its determinants in controls and in patients with moderate HF and reduced ejection fraction (HFrEF). METHODS AND RESULTS:

Automatic Tags

β-Hydroxybutyrate; Heart failure; Ketone ester; Exogenous ketones; Myocardial metabolism; β-Oxidation