top of page
A KETOGENIC DIET COMBINED WITH EXERCISE ALTERS MITOCHONDRIAL FUNCTION IN HUMAN SKELETAL MUSCLE WHILE IMPROVING METABOLIC HEALTH
Miller, Vincent J; LaFountain, Richard A; Barnhart, Emily; Sapper, Teyrn S; Short, Jay; Arnold, William David; Hyde, Parker N; Crabtree, Christopher D; Kackley, Madison L; Kraemer, William J.; Villamena, Frederick; Volek, Jeffrey S.
Abstract:
Animal data indicate that ketogenic diets are associated with improved mitochondrial function, but human data are lacking. We aimed to characterize skeletal muscle mitochondrial changes in response to a ketogenic diet combined with exercise training in healthy individuals. Twenty-nine physically active adults completed a 12-week supervised exercise program after self-selection into a ketogenic diet (KD, n=15) group or maintenance of their habitual mixed diet (MD, n=14). Measures of metabolic health and muscle biopsies (Vastus lateralis) were obtained before and after the intervention. Mitochondria were isolated from muscle and studied after exposure to carbohydrate (pyruvate), fat (palmitoyl-L-carnitine), and ketone (β-hydroxybutyrate+acetoacetate) substrates. Compared to MD, the KD resulted in increased whole-body resting fat oxidation (p<0.001) and decreased fasting insulin (p=0.019), insulin resistance (HOMA-IR, p=0.022), and visceral fat (p
Automatic Tags
bottom of page