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The effect of calcium supplementation on blood lead levels in Nigerian children

Keating, Elizabeth M.; Fischer, Philip R.; Pettifor, John M.; Pfitzner, Mark; Isichei, Christian O.; Thacher, Tom D.

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PMID: 21665223


OBJECTIVE: To determine whether calcium supplementation alters the risk of lead toxicity. STUDY DESIGN: Children aged 12-18 months from 3 communities in Nigeria were assigned to receive daily calcium supplementation, as either calcium carbonate (400 mg) or ground dried fish (529 ± 109 mg), or placebo. All children received 2500 IU of vitamin A. Levels of blood lead, calcium, and vitamin D metabolites were measured at baseline and after 12-18 months (n = 358). RESULTS: The mean (± SD) baseline lead level was 11.1 ± 7.8 μg/dL (range, 1-43 μg/dL; median, 9 μg/dL); 44.7% of subjects had a lead level >10 μg/dL. After 12-18 months, the mean lead level was 8.1 ± 6.3 μg/dL (range, 1-48 μg/dL; median, 6 μg/dL), with 22.6% with a level >10 μg/dL. Lead levels at baseline varied among communities (P = .01) and were higher in children who used eye cosmetics or lived near a lead-acid battery melter (both P

Automatic Tags

Female; Humans; Male; Infant; Age Factors; Dietary Supplements; Vitamins; Food, Formulated; Multivariate Analysis; Vitamin A; Nigeria; Fish Products; Calcium Carbonate; Cosmetics; Electric Power Supplies; Lead; Residence Characteristics

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