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Body fat and animal protein intakes are associated with adrenal androgen secretion in children

Shi L; Wudy SA; Buyken AE; Hartmann MF; Remer T

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BACKGROUND: Adrenarche is the increase in adrenal androgen (AA) production starting in childhood. Until now, it has been unknown whether or not nutritional factors modulate adrenarche. OBJECTIVE: The objective was to examine whether body composition and certain dietary intakes are associated with AA production in children after accounting for urinary indicators of major adrenarche-related steroidogenic enzymes. DESIGN: Androgen and glucocorticoid metabolites were profiled by gas chromatography-mass spectrometry in 24-h urine samples of 137 healthy prepubertal children aged 3-12 y, for whom birth characteristics, growth velocity data, and 3-d weighed-diet record information were available. Associations of the sum of C19 metabolites (reflecting daily AA secretion) with nutritional factors [fat mass (FM), fat-free mass (FFM), nutrient intakes, glycemic index, and glycemic load] and AA-relevant estimates of steroidogenic enzyme were examined in stepwise multiple regression models adjusted for age, sex, urine volume, and total energy intake. Enzyme activity estimates were calculated by using specific urinary steroid metabolite ratios. RESULTS: Of the nutrition-relevant predictors, FM (P < 0.0001) explained most of the variation of AA secretion (R(2) = 5%). Animal protein intake was also positively associated with AA secretion (P

Automatic Tags

Female; Male; Child; Child, Preschool; Prospective Studies; Human; Child Development; Germany; Chromatography, Gas; Cross Sectional Studies; Mass Spectrometry; Data Analysis Software; Descriptive Statistics; Funding Source; Analysis of Covariance; Body Composition -- In Infancy and Childhood; Body Mass Index -- In Infancy and Childhood; Body Weights and Measures -- In Infancy and Childhood; Chi Square Test; Child Health; Child Nutrition; Diet Records -- In Infancy and Childhood; Growth -- In Infancy and Childhood; Nutritional Assessment -- In Infancy and Childhood; Unpaired T-Tests; Whites; Diet -- In Infancy and Childhood; Step-Wise Multiple Regression; Adrenal Glands -- Metabolism -- In Infancy and Childhood; Androgens -- Metabolism -- In Infancy and Childhood; Dehydroepiandrosterone -- Urine -- In Infancy and Childhood; Dietary Proteins -- In Infancy and Childhood; Glucocorticoids -- In Infancy and Childhood; Meat -- In Infancy and Childhood; Skinfold Thickness -- In Infancy and Childhood; Urinalysis -- In Infancy and Childhood

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