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Plasma alkylresorcinols, biomarkers of whole-grain intake, are related to lower BMI in older adults

Ma, Jiantao; Ross, Alastair B.; Shea, M. Kyla; Bruce, Stephen J.; Jacques, Paul F.; Saltzman, Edward; Lichtenstein, Alice H.; Booth, Sarah L.; McKeown, Nicola M.

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PMID: 22955514 PMCID: PMC3442796


Alkylresorcinols (AR) are phenolic lipids found in the bran fraction of whole-grain wheat, rye, and barley. In intervention studies, plasma AR concentration increased in response to greater intakes of whole grain, wheat, and rye. This study examined the cross-sectional associations between plasma AR and habitual whole-grain intake, BMI, and metabolic risk factors in 407 free-living older adults (166 men and 241 women; aged 60-81y; median BMI: 27 kg/m(2)). Plasma AR were measured by liquid chromatography-tandem MS, and whole-grain intakes were estimated by using an FFQ. After adjustment for fasting TG concentrations, median plasma AR concentrations across quartile categories of AR were 5, 14, 27, and 62 nmol/L, respectively. Spearman correlation coefficients between plasma AR and whole-grain wheat-rich foods and total bran intake were 0.31 and 0.27, respectively (both P

Automatic Tags

Female; Humans; Male; Cross-Sectional Studies; Aged; Aged, 80 and over; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Body Mass Index; Energy Intake; Feeding Behavior; Body Composition; Biomarkers; Dietary Fiber; Edible Grain; Resorcinols

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