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Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: a randomized clinical trial of dietary fish and n-3 fatty acid capsules

Straka, Shana; Lester, Joanne L.; Cole, Rachel M.; Andridge, Rebecca R.; Puchala, Sarah; Rose, Angela M.; Clinton, Steven K.; Belury, Martha A.; Yee, Lisa D.

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PMID: 26081224


SCOPE: The fatty acid profile of dietary lipids is reflected in mammary adipose tissue and may influence mammary gland biology and cancer risk. To determine the effects of fish consumption on breast adipose tissue fatty acids, we conducted a study of fish versus n-3 PUFA supplements in women at increased risk of breast cancer. METHODS AND RESULTS: High risk women were randomized to comparable doses of marine n-3 PUFAs as canned salmon + albacore or capsules for 3 months. Pre- and posttreatment fatty acid profiles were obtained by GC. Dietary fish (n = 12) and n-3 PUFA capsules (n = 13) yielded increased eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in plasma (p < 0.0001), erythrocyte membranes (p < 0.0001), and breast fat (p

Automatic Tags

Female; Humans; Adult; Young Adult; Aged; Aged, 80 and over; Middle Aged; Risk Factors; Body Mass Index; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Adipose Tissue; Erythrocyte Membrane; Interleukin-6; DHA; EPA; Dose-Response Relationship, Drug; Seafood; Breast Neoplasms; Fishes; Capsules; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Breast; Breast adipose tissue; Cyclooxygenase 2; Dietary fish; n-3 PUFAs

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