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Probiotics during weaning: a follow-up study on effects on body composition and metabolic markers at school age

Karlsson Videhult, Frida; Öhlund, Inger; Stenlund, Hans; Hernell, Olle; West, Christina

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Purpose: An aberrant gut microbiome has been suggested to contribute to the worldwide epidemic of obesity. In animal models, the probiotic Lactobacillus paracasei ssp. paracasei F19 (LF19) induced upregulation of genes involved in energy homoeostasis, reduced body fat and altered the serum (S) lipoprotein profile. In our previous report, feeding LF19 to infants during weaning impacted the global plasma metabolome. LF19 lowered palmitoleic acid, a monounsaturated fatty acid associated with hypertriglyceridemia and increased visceral adiposity. Therefore, we assessed if feeding LF19 from 4 to 13 months of age would have long-term effects on body composition, growth and metabolic markers. Methods: Of 179 children included in our baseline study, 120 entered the follow-up at 8-9 years of age, n = 58 in the probiotic and n = 62 in the placebo group. Body composition was measured using dual energy X-ray absorptiometry. Anthropometrics of the child and accompanying parent(s) were assessed. S-lipids, insulin, glucose and transaminases were determined after overnight fasting. Results: LF19 did not affect body mass index z-score, sagittal abdominal diameter, fat-free mass, fat mass index, truncal fat %, android or gynoid fat % and had no long-term impact on any of the assessed metabolic markers ( p > 0.05). Conclusion: Feeding LF19 during infancy did not modulate body composition, growth or any of the assessed metabolic markers at school age. The steady increase in probiotic products targeting infants and children calls for long-term follow-up of initiated probiotic intervention studies.

Automatic Tags

Female; Male; Adult; Child; Infant; Prospective Studies; Human; Child Development; Sweden; Confidence Intervals; Parents; Birth Weight; Gestational Age; Randomized Controlled Trials; Data Analysis Software; Descriptive Statistics; Funding Source; Random Assignment; P-Value; Spearman's Rank Correlation Coefficient; Absorptiometry, Photon -- In Infancy and Childhood; Analysis of Covariance; Blood Glucose -- In Infancy and Childhood; Body Composition -- In Infancy and Childhood; Body Mass Index -- In Infancy and Childhood; Body Weights and Measures -- In Infancy and Childhood; Chi Square Test; Child Health; Child Nutrition; Child Nutritional Physiology; Diet Records -- In Infancy and Childhood; Double-Blind Studies; Enzymes -- In Infancy and Childhood; Growth -- In Infancy and Childhood; Infant Nutrition; Infant Nutritional Physiology; Insulin -- Blood -- In Infancy and Childhood; Lactobacillus -- In Infancy and Childhood; Metabolism -- In Infancy and Childhood; Nutritional Assessment -- In Infancy and Childhood; Pedometers -- In Infancy and Childhood; Physical Activity -- In Infancy and Childhood; Power Analysis; Probiotics -- Administration and Dosage -- In Infancy and Childhood; T-Tests; Weaning -- In Infancy and Childhood; World Health Organization -- Standards

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