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Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial

Cho, Clara E.; Taesuwan, Siraphat; Malysheva, Olga V.; Bender, Erica; Tulchinsky, Nathan F.; Yan, Jian; Sutter, Jessica L.; Caudill, Marie A.

Date Published:





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PMID: 27377678


SCOPE: Trimethylamine-N-oxide (TMAO), a metabolite linked to the gut microbiota, is associated with excess risk of heart disease. We hypothesized that (i) TMAO response to animal source foods would vary among healthy men and (ii) this response would be modified by their gut microbiome. METHODS AND RESULTS: A crossover feeding trial in healthy young men (n = 40) was conducted with meals containing TMAO (fish), its dietary precursors, choline (eggs) and carnitine (beef), and a fruit control. Fish yielded higher circulating and urinary concentrations of TMAO (46-62 times; p < 0.0001), trimethylamine (8-14 times; p < 0.0001), and dimethylamine (4-6-times; P

Automatic Tags

Humans; Male; Adult; Metabolism; Middle Aged; Biomarkers; Food; Human; Gastrointestinal Microbiome; Meat; Dietary precursor intake; Methylamines; Trimethylamine-N-oxide; *Dietary precursor intake; *Gut microbiota; *Human; *Metabolism; *Trimethylamine-N-oxide

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