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ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye

Walter, Scott D.; Gronert, Karsten; McClellan, Allison L.; Levitt, Roy C.; Sarantopoulos, Konstantinos D.; Galor, Anat

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PMID: 27138739 PMCID: PMC4857833


PURPOSE: ω-3 and ω-6 polyunsaturated fatty acids modulate inflammatory processes throughout the body through distinct classes of lipid mediators that possess both proinflammatory and proresolving properties. The purpose of this cross-sectional study was to explore the relationship between lipid profiles in human tears and dry eye (DE) symptoms and signs. METHODS: Forty-one patients with normal eyelid and corneal anatomy were prospectively recruited from a Veterans Administration Hospital over 18 months. Symptoms and signs of DE were assessed, and tear samples was analyzed by mass spectrometry-based lipidomics. Statistical analyses comparing the relationship between tear film lipids and DE included Pearson/Spearman correlations and t-tests. RESULTS: Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) were present in more than 90% of tear film samples. The ratio of ω-6 (AA) to ω-3 (DHA+EPA) fatty acids was correlated with multiple measures of tear film dysfunction (tear breakup time, Schirmer 2 scores, and corneal staining; all P

Automatic Tags

Female; Humans; Male; Adult; Cross-Sectional Studies; Retrospective Studies; Aged; Aged, 80 and over; Middle Aged; Fatty Acids, Omega-3; Mass Spectrometry; Tears; Dry Eye Syndromes; Cornea; Sensory Thresholds

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