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The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis
Smolinska, A.; Bodelier, A. G. L.; Dallinga, J. W.; Masclee, A. a. M.; Jonkers, D. M.; van Schooten, F.-J.; Pierik, M. J.
Abstract:
BACKGROUND: To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non-invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non-UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease. AIM: To investigate whether VOCs are able to differentiate between active UC, UC in remission and non-UC colitis. METHODS: UC patients participated in a 1-year study. Clinical activity index, blood, faecal and breath samples were collected at each out-patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index <3, C-reactive protein <5 mg/L and faecal calprotectin
Automatic Tags
Female; Humans; Male; Adult; Cross-Sectional Studies; Aged; Aged, 80 and over; Middle Aged; Colitis; Biomarkers; C-Reactive Protein; Sensitivity and Specificity; Outpatients; Leukocyte L1 Antigen Complex; Breath Tests; Gas Chromatography-Mass Spectrometry; Feces; Volatile Organic Compounds
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