top of page
< Back

Human metabolic phenotype diversity and its association with diet and blood pressure

Holmes, Elaine; Loo, Ruey Leng; Stamler, Jeremiah; Bictash, Magda; Yap, Ivan K. S.; Chan, Queenie; Ebbels, Tim; De Iorio, Maria; Brown, Ian J.; Veselkov, Kirill A.; Daviglus, Martha L.; Kesteloot, Hugo; Ueshima, Hirotsugu; Zhao, Liancheng; Nicholson, Jeremy K.; Elliott, Paul

Date Published:





Extra Links:

May 15, 2008


PMID: 18425110 PMCID: PMC6556779


Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. Metabolites discriminating across populations are then linked to data for individuals on blood pressure, a major risk factor for coronary heart disease and stroke (leading causes of mortality worldwide). We analyse spectra from two 24-hour urine specimens for each of 4,630 participants from the INTERMAP epidemiological study, involving 17 population samples aged 40-59 in China, Japan, UK and USA. We show that urinary metabolite excretion patterns for East Asian and western population samples, with contrasting diets, diet-related major risk factors, and coronary heart disease/stroke rates, are significantly differentiated (P < 10(-16)), as are Chinese/Japanese metabolic phenotypes, and subgroups with differences in dietary vegetable/animal protein and blood pressure. Among discriminatory metabolites, we quantify four and show association (P < 0.05 to P

Automatic Tags

Female; Humans; Male; China; Adult; Metabolism; Middle Aged; Diet; Magnetic Resonance Spectroscopy; Time Factors; Blood Pressure; United Kingdom; Intestines; Dietary Proteins; Phenotype; Japan; Vegetables; Principal Component Analysis; Alanine; Hippurates

bottom of page