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Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk

Canales, A.; Sánchez-Muniz, F. J.; Bastida, S.; Librelotto, J.; Nus, M.; Corella, D.; Guillen, M.; Benedi, J.

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PMID: 21407247


BACKGROUND/OBJECTIVE: Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4). SUBJECTS/METHODS: In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4-6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed. RESULTS: Individuals consuming walnut-enriched meat displayed higher paraoxonase activity (P<0.001), lower levels of sICAM and aVCAM (P=0.046, P=0.012, respectively) and leukotriene B4 (P=0.044), and lower paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios (both, P<0.001) than those consuming LM. Paraoxonase levels correlated negatively with those of sICAM (r=-0.471, P<0.01). Significant decreases (at least P

Automatic Tags

Female; Humans; Male; Middle Aged; Risk Factors; Diet; Polymorphism, Genetic; Cholesterol, HDL; Vascular Cell Adhesion Molecule-1; Meat; Apolipoprotein A-I; Inflammation Mediators; Food, Fortified; Nuts; Plant Preparations; Aryldialkylphosphatase; Apolipoproteins A; Juglans; Cell Adhesion Molecules; Intercellular Adhesion Molecule-1; Leukotriene B4

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