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High intake of milk, but not meat, decreases bone turnover in prepubertal boys after 7 days

Budek, A. Z.; Hoppe, C.; Michaelsen, K. F.; Mølgaard, C.

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PMID: 17228345


OBJECTIVE: To compare the short-term effect of a high milk and a high meat intake, identical in protein amount, on bone turnover during prepuberty. SETTING: A University department. DESIGN AND SUBJECTS: From 28, randomly recruited, 8-year-old boys, first 14 were assigned to the milk group and next 14 to the meat group. In each group, 12 boys finished the dietary intervention. INTERVENTION: Milk (1.5 l/day) and meat (250 g/d), both containing approximately 53 g of protein, were given together with the habitual diet for 7 days. At baseline and day-7, serum osteocalcin (s-OC), bone-specific alkaline phosphatase (s-BAP) and C-terminal telopeptides of type I collagen (s-CTX) were measured (immunoassay) and dietary intake was estimated (a 3-day weighted food record). RESULTS: Baseline s-OC, s-BAP and s-CTX were not significantly different between the groups. After 7 days, the average protein intake increased in both groups by 47.5 g; the milk group had higher (P<0.0001) calcium intake; s-OC and s-CTX decreased (P

Automatic Tags

Humans; Male; Bone Remodeling; Child; Biomarkers; Bone and Bones; Osteocalcin; Bone Density; Human; Dietary Proteins; Meat; Alkaline Phosphatase; Collagen Type I; Peptides; Puberty; Biological Markers -- Blood; Milk Proteins; Bone Remodeling -- Drug Effects; Collagen -- Blood; Bone and Bones -- Metabolism; Osteocalcin -- Blood; Milk Proteins -- Pharmacodynamics; Alkaline Phosphatase -- Blood; Bone Remodeling -- Physiology; Dietary Proteins -- Pharmacodynamics; Peptides -- Blood; Puberty -- Physiology

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