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Sexual Dimorphism, Age, and Fat Mass Are Key Phenotypic Drivers of Proteomic Signatures

Curran, Aoife M.; Fogarty Draper, Colleen; Scott-Boyer, Marie-Pier; Valsesia, Armand; Roche, Helen M.; Ryan, Miriam F.; Gibney, Michael J.; Kutmon, Martina; Evelo, Chris T.; Coort, Susan L.; Astrup, Arne; Saris, Wim H.; Brennan, Lorraine; Kaput, Jim

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PMID: 28950061


Validated protein biomarkers are needed for assessing health trajectories, predicting and subclassifying disease, and optimizing diagnostic and therapeutic clinical decision-making. The sensitivity, specificity, accuracy, and precision of single or combinations of protein biomarkers may be altered by differences in physiological states limiting the ability to translate research results to clinically useful diagnostic tests. Aptamer based affinity assays were used to test whether low abundant serum proteins differed based on age, sex, and fat mass in a healthy population of 94 males and 102 females from the MECHE cohort. The findings were replicated in 217 healthy male and 377 healthy female participants in the DiOGenes consortium. Of the 1129 proteins in the panel, 141, 51, and 112 proteins (adjusted p

Automatic Tags

Humans; Male; Sex Characteristics; Age Factors; fat mass; male; biomarker; Adipose Tissue; protein; Phenotype; Proteomics; age; sex; phenotype; proteomics; pathway

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