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Acceleration of BMI in Early Childhood and Risk of Sustained Obesity

Geserick, Mandy; Vogel, Mandy; Gausche, Ruth; Lipek, Tobias; Spielau, Ulrike; Keller, Eberhard; Pfäffle, Roland; Kiess, Wieland; Körner, Antje

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ISBN: 0028-4793 1533-4406 PMID: 30281992


Abstract Background The dynamics of body-mass index (BMI) in children from birth to adolescence are unclear, and whether susceptibility for the development of sustained obesity occurs at a specific age in children is important to determine. Methods To assess the age at onset of obesity, we performed prospective and retrospective analyses of the course of BMI over time in a population-based sample of 51,505 children for whom sequential anthropometric data were available during childhood (0 to 14 years of age) and adolescence (15 to 18 years of age). In addition, we assessed the dynamics of annual BMI increments, defined as the change in BMI standard-deviation score per year, during childhood in 34,196 children. Results In retrospective analyses, we found that most of the adolescents with normal weight had always had a normal weight throughout childhood. Approximately half (53%) of the obese adolescents had been overweight or obese from 5 years of age onward, and the BMI standard-deviation score further inc...

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Female; Humans; Male; Adolescent; Adult; Mental Health; Inflammation; Aging; Health Status; Child; Young Adult; Aged; Middle Aged; Exercise; Cognition; Neuropsychological Tests; Triglycerides; Cholesterol; Energy Intake; Micronutrients; Dietary Supplements; Magnetic Resonance Spectroscopy; Nutritional Status; Fatty Acids, Omega-3; Dietary Fats, Unsaturated; Chromatography, High Pressure Liquid; Insulin Resistance; Analysis of Variance; Diet, Mediterranean; Biomarkers; Lipids; Fasting; Single-Blind Method; Prospective Studies; Hypertension; Food; Treatment Outcome; Vitamin B 12 Deficiency; Reaction Time; Australia; Insulin; Postmenopause; Smoking; Eating; Cross-Over Studies; Cholesterol, HDL; Human; Oxidation-Reduction; New Zealand; Well-being; Pain; Vitamins; Microbiome; Dietary Proteins; Antioxidants; Food Analysis; Meat; Metabolomics; Cattle; Cholesterol, LDL; Child Nutritional Physiological Phenomena; Homocysteine; Ferritins; Up-Regulation; Methylation; Intestinal Absorption; Confidence Intervals; Milk; Statistics, Nonparametric; Oleic Acid; Proteins; Zinc; Deficiency Diseases; Flavonoids; iron; Executive Function; Lipoproteins, LDL; Hemoglobins; Rural Population; Vitamin A; Iron; Red meat; Dementia; Amino Acids; Cooking; Eggs; Food, Fortified; Vegetables; Snacks; Breast Neoplasms; Iron, Dietary; Swine; Estrogens; Fishes; Avitaminosis; Psychomotor Performance; Cognition Disorders; Fatty Acids, Omega-6; Middle Age; Untargeted metabolomics; Multicenter Studies; Urinalysis; Descriptive Statistics; Funding Source; Diabetes Mellitus, Type 2 -- Risk Factors; Proteomics; Pork; Biological Markers -- Blood; Adolescence; Folate; Biomarker; Iron Supplement; Vitamin B6; Statistics as Topic; Blood Platelets; Personalized medicine; Milk Proteins; Intelligence Tests; Monitoring, Physiologic; Biological Markers -- Therapeutic Use; Ferritin; Lipids -- Metabolism; Dead pork meat; Live pork meat; Pseudotargeted metabolomics; UHPLC–QTRAP–MS; UHPLC–Triple–TOF–MS; Ferritin -- Blood; Age-related cognitive function; Study protocol; Molecular epidemiology; Patient related outcome measures (PROMs); Treatment outcome; High protein diet; MaoB; Platelet proteomics; Epidemiological studies; Metabolic phenotyping; animal-source food; micronutrient status; reproductive-age women; Vietnam; Vitamin A Deficiency; Hemoglobins -- Metabolism; Iron Compounds -- Administration and Dosage; Pain -- Epidemiology; Hippurates; Electrophoresis, Gel, Two-Dimensional; Monoamine Oxidase; Onions; Quercetin; Animal-source food; Micronutrient status; Reproductive-age women

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