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Influence of moderate energy restriction and seafood consumption on bone turnover in overweight young adults

Lucey, Alice J.; Paschos, George K.; Cashman, Kevin D.; Martínéz, J. Alfredo; Thorsdottir, Inga; Kiely, Máireád

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PMID: 18400730


BACKGROUND: Overweight and obesity are increasing in young adults. However, moderate energy restriction aimed at lowering body weight may promote bone turnover and bone loss. Inclusion of fish or fish oils in a weight-loss diet may attenuate these adverse skeletal effects. OBJECTIVE: We examined the effects of incorporating fish or fish oil into an energy-restricted diet on bone turnover markers in young overweight adults. DESIGN: While following a strict hypoenergetic (-30% relative to estimated requirements) diet for 8 wk, 276 overweight men and women [body mass index (in kg/m(2)): 27.5-32.5; age: 20-40 y) were randomly assigned to 1 of 4 dietary groups: sunflower-oil capsules (3 g/d; control), cod (3 x 150 g/wk), salmon (3 x 150 g/wk), and fish-oil capsules (3 g/d). Body weight, bone biomarkers, and 25-hydroxyvitamin D were measured at baseline and endpoint. Data were analyzed with repeated-measures analysis of variance and general linear models. RESULTS: The mean (+/-SD) weight loss was 5.14 +/- 3.0 kg (5.8% +/- 3.2% body weight) during the 8 wk in the 4 dietary groups combined. Urinary N-telopeptides of type I collagen and serum C-terminal telopeptide of type I collagen increased (P < 0.05), whereas serum osteocalcin (but not bone-specific alkaline phosphatase) decreased (P 0.1) on the changes in bone markers induced by weight loss. In contrast, increased salmon consumption increased serum 25-hydroxyvitamin D (P

Automatic Tags

Female; Humans; Male; Adult; Plant Oils; Body Mass Index; Dietary Supplements; Fish Oils; Analysis of Variance; Biomarkers; Diet, Reducing; Treatment Outcome; Linear Models; Bone and Bones; Osteocalcin; Vitamin D; Overweight; Seafood; Sunflower Oil; Bone Resorption; Salmon; Gadiformes

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