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A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
Pasanisi, Patrizia; Bruno, Eleonora; Venturelli, Elisabetta; Morelli, Daniele; Oliverio, Andreina; Baldassari, Ivan; Rovera, Francesca; Iula, Giovanna; Taborelli, Monica; Peissel, Bernard; Azzollini, Jacopo; Manoukian, Siranoush
Abstract:
Background: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the 'Mediterranean diet', with moderate protein restriction, on serum levels of IGF-I and IRm. Methods: BRCA mutation carriers, with or without breast cancer, aged 18–70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group. The intervention group attended six full days of life-style intervention activities (cookery classes followed by lunch, sessions of walking for 45 min and nutritional conferences) over the next six months. Results: 213 BRCA mutation carriers completed the six-month study. Women in the intervention group (110) showed major changes in all the parameters under study. They significantly lost weight (p
Automatic Tags
Female; Adult; Young Adult; Time Factors; Life Style; Nutrition; Waist Circumference; Human; Adipose Tissue; Phenotype; Meat; Mutation; Mediterranean Diet; Walking; Randomized Controlled Trials; Middle Age; Biological Markers -- Blood; Triglycerides -- Blood; Adolescence; Neoplasm Metastasis; Breast Neoplasms -- Diet Therapy; Breast Neoplasms -- Familial and Genetic; Congresses and Conferences; Genes, BRCA; Insulin Resistance -- Blood; Somatomedins -- Blood
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