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A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression: The Role of Baseline Inflammatory Biomarkers
Raison, Charles L.; Rutherford, Robin E.; Woolwine, Bobbi J.; Shuo, Chen; Schettler, Pamela; Drake, Daniel F.; Haroon, Ebrahim; Miller, Andrew H.
Abstract:
Context—Increased inflammatory biomarkers predict antidepressant non-response, and inflammatory cytokines can sabotage and circumvent mechanisms of action of conventional antidepressant therapy.
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