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The association of substituting carbohydrates with total fat and different types of fatty acids with mortality and weight change among diabetes patients

Campmans-Kuijpers, Marjo J.; Sluijs, Ivonne; Nothlings, Ute; Freisling, Heinz; Overvad, Kim; Boeing, Heiner; Masala, Giovanna; Panico, Salvatore; Tumino, Rosario; Sieri, Sabina; Johansson, Ingegerd; Winkvist, Anna; Katzke, Verena A.; Kuehn, Tilman; Nilsson, Peter M.; Halkjaer, Jytte; Tjonneland, Anne; Spijkerman, Annemieke M.; Arriola, Larraitz; Sacerdote, Carlotta; Barricarte, Aurelio; May, Anne M.; Beulens, Joline W.

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2016

10.1016/j.clnu.2015.08.003

PMID: 26342536

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Abstract:

CONCLUSIONS: In diabetes patients, substitution of carbohydrates with SFAs was associated with a higher (CVD) mortality risk and substitution by total fat was associated with a higher all-cause mortality risk. Substitution of carbohydrates with MUFAs may be associated with lower mortality risk and weight reduction. Instead of promoting replacement of carbohydrates by total fat, dietary guideline should continue focusing on replacement by fat-subtypes; especially SFAs by MUFAs. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.