The molecular basis of nutritional intervention in multiple sclerosis: A narrative review

Inflammation; Nutrition; Autoimmunity; Multiple sclerosis; Omega-3 fatty acids; Polyphenols; PPAR; Transcription factors; AMPK, AMP protein kinase; ChREBP, carbohydrate responsive element-binding protein; ICAM-1, intercellular adhesion molecule; LXR, liver X receptor; MMP, metalloproteinase; n-3 PUFA, omega-3 polyunsaturated fatty acids; NF-kB; NF-kB, nuclear transcription factor-kB; PPAR, peroxisome proliferator activated receptor; ROS, reactive oxygen species; RXR, retinoid X-receptor; SIRT-1/2, sirtuin-1/2, deacetylating enzyme; SREBP, steroid regulatory element-binding protein; TNF, tumor necrosis factor; VCAM-1, vascular adhesion molecule; VEGF, vascular endothelial growth factor