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Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences
Horne, B. D.; Muhlestein, J. B.; Lappé, D. L.; May, H. T.; Carlquist, J. F.; Galenko, O.; Brunisholz, K. D.; Anderson, J. L.
Abstract:
BACKGROUND AND AIMS: Routine, periodic fasting is associated with a lower prevalence of coronary artery disease (CAD). Animal studies show that fasting may increase longevity and alter biological parameters related to longevity. We evaluated whether fasting initiates acute changes in biomarker expression in humans that may impact short- and long-term health. METHODS AND RESULTS: Apparently-healthy volunteers (N = 30) without a recent history of fasting were enrolled in a randomized cross-over trial. A one-day water-only fast was the intervention and changes in biomarkers were the study endpoints. Bonferroni correction required p ≤ 0.00167 for significance (p
Automatic Tags
Female; Humans; Male; Adult; Middle Aged; Triglycerides; Risk Factors; Body Mass Index; Biomarkers; Fasting; Diabetes Mellitus, Type 2; Metabolic Syndrome; Cross-Over Studies; Energy restriction; Hypertriglyceridemia; Caloric restriction; Water; Erythrocyte; FGF-21; Hemoglobin; Human growth hormone; Utah
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