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Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial

Kahn, René S; Fleischhacker, W Wolfgang; Boter, Han; Davidson, Michael; Vergouwe, Yvonne; Keet, Ireneus PM; Gheorghe, Mihai D; Rybakowski, Janusz K; Galderisi, Silvana; Libiger, Jan; Hummer, Martina; Dollfus, Sonia; López-Ibor, Juan J; Hranov, Luchezar G; Gaebel, Wolfgang; Peuskens, Joseph; Lindefors, Nils; Riecher-Rössler, Anita; Grobbee, Diederick E

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2008-03

10.1016/S0140-6736(08)60486-9

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Abstract:

Background Second-generation antipsychotic drugs were introduced over a decade ago for the treatment of schizophrenia; however, their purported clinical eﬀectiveness compared with ﬁrst-generation antipsychotic drugs is still debated. We aimed to compare the eﬀectiveness of second-generation antipsychotic drugs with that of a low dose of haloperidol, in ﬁrst-episode schizophrenia.