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A comprehensive analysis of mortality-related health metrics associated with mental disorders: a nationwide, register-based cohort study

Plana-Ripoll, Oleguer; Pedersen, Carsten Bøcker; Agerbo, Esben; Holtz, Yan; Erlangsen, Annette; Canudas-Romo, Vladimir; Andersen, Per Kragh; Charlson, Fiona J; Christensen, Maria K; Erskine, Holly E; Ferrari, Alize J; Iburg, Kim Moesgaard; Momen, Natalie; Mortensen, Preben Bo; Nordentoft, Merete; Santomauro, Damian F; Scott, James G; Whiteford, Harvey A; Weye, Nanna; McGrath, John J; Laursen, Thomas M

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10.1016/S0140-6736(19)32316-5

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Abstract:

BackgroundSystematic reviews have consistently shown that individuals with mental disorders have an increased risk of premature mortality. Traditionally, this evidence has been based on relative risks or crude estimates of reduced life expectancy. The aim of this study was to compile a comprehensive analysis of mortality-related health metrics associated with mental disorders, including sex-specific and age-specific mortality rate ratios (MRRs) and life-years lost (LYLs), a measure that takes into account age of onset of the disorder.