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The role of fatty acid β-oxidation in lymphangiogenesis

Wong, Brian W.; Wang, Xingwu; Zecchin, Annalisa; Thienpont, Bernard; Cornelissen, Ivo; Kalucka, Joanna; García-Caballero, Melissa; Missiaen, Rindert; Huang, Hongling; Brüning, Ulrike; Blacher, Silvia; Vinckier, Stefan; Goveia, Jermaine; Knobloch, Marlen; Zhao, Hui; Dierkes, Cathrin; Shi, Chenyan; Hägerling, René; Moral-Dardé, Veronica; Wyns, Sabine; Lippens, Martin; Jessberger, Sebastian; Fendt, Sarah-Maria; Luttun, Aernout; Noel, Agnès; Kiefer, Friedemann; Ghesquière, Bart; Moons, Lieve; Schoonjans, Luc; Dewerchin, Mieke; Eelen, Guy; Lambrechts, Diether; Carmeliet, Peter

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2017-02

10.1038/nature21028

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Abstract:

The lymphangiogenic factor PROX1 transcriptionally upregulates CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, and this co-regulates lymphatic endothelial cell differentiation by epigenetic control of lymphatic gene expression, demonstrating a role for metabolism in developmental biology.