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Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

Meddens, S. Fleur W.; de Vlaming, Ronald; Bowers, Peter; Burik, Casper A. P.; Linnér, Richard Karlsson; Lee, Chanwook; Okbay, Aysu; Turley, Patrick; Rietveld, Cornelius A.; Fontana, Mark Alan; Ghanbari, Mohsen; Imamura, Fumiaki; McMahon, George; van der Most, Peter J.; Voortman, Trudy; Wade, Kaitlin H.; Anderson, Emma L.; Braun, Kim V. E.; Emmett, Pauline M.; Esko, Tonũ; Gonzalez, Juan R.; Kiefte-de Jong, Jessica C.; Langenberg, Claudia; Luan, Jian’an; Muka, Taulant; Ring, Susan; Rivadeneira, Fernando; Snieder, Harold; van Rooij, Frank J. A.; Wolffenbuttel, Bruce H. R.; Smith, George Davey; Franco, Oscar H.; Forouhi, Nita G.; Ikram, M. Arfan; Uitterlinden, Andre G.; van Vliet-Ostaptchouk, Jana V.; Wareham, Nick J.; Cesarini, David; Harden, K. Paige; Lee, James J.; Benjamin, Daniel J.; Chow, Carson C.; Koellinger, Philipp D.

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May 11, 2020

10.1038/s41380-020-0697-5

Publisher: Nature Publishing Group

Abstract:

We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 × 10−8), while five of the 21 lead SNPs reach suggestive significance (P 

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