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IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Omer F.; Frahnow, Turid; Simon, Lukas; Greene, Stephanie; Zeng, Qingping; Fazli, Ladan; Rennie, Paul S.; Mills, Ian G.; Danielsen, Håvard; Theis, Fabian; Patterson, John B.; Jin, Yang; Saatcioglu, Fahri

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January 24, 2019

10.1038/s41467-018-08152-3

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Abstract:

ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinically used prostate cancer drugs.