< Back

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Harris, William S.; Tintle, Nathan L.; Imamura, Fumiaki; Qian, Frank; Korat, Andres V. Ardisson; Marklund, Matti; Djoussé, Luc; Bassett, Julie K.; Carmichael, Pierre-Hugues; Chen, Yun-Yu; Hirakawa, Yoichiro; Küpers, Leanne K.; Laguzzi, Federica; Lankinen, Maria; Murphy, Rachel A.; Samieri, Cécilia; Senn, Mackenzie K.; Shi, Peilin; Virtanen, Jyrki K.; Brouwer, Ingeborg A.; Chien, Kuo-Liong; Eiriksdottir, Gudny; Forouhi, Nita G.; Geleijnse, Johanna M.; Giles, Graham G.; Gudnason, Vilmundur; Helmer, Catherine; Hodge, Allison; Jackson, Rebecca; Khaw, Kay-Tee; Laakso, Markku; Lai, Heidi; Laurin, Danielle; Leander, Karin; Lindsay, Joan; Micha, Renata; Mursu, Jaako; Ninomiya, Toshiharu; Post, Wendy; Psaty, Bruce M.; Risérus, Ulf; Robinson, Jennifer G.; Shadyab, Aladdin H.; Snetselaar, Linda; Sala-Vila, Aleix; Sun, Yangbo; Steffen, Lyn M.; Tsai, Michael Y.; Wareham, Nicholas J.; Wood, Alexis C.; Wu, Jason H. Y.; Hu, Frank; Sun, Qi; Siscovick, David S.; Lemaitre, Rozenn N.; Mozaffarian, Dariush

Date Published:

Publication:

DOI:

URL:

PMID:

Extra Links:

April 22, 2021

10.1038/s41467-021-22370-2

Click to open url

Number: 1 Publisher: Nature Publishing Group

Abstract:

The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p