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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Tameire, Feven; Verginadis, Ioannis I.; Leli, Nektaria Maria; Polte, Christine; Conn, Crystal S.; Ojha, Rani; Salinas, Carlo Salas; Chinga, Frank; Monroy, Alexandra M.; Fu, Weixuan; Wang, Paul; Kossenkov, Andrew; Ye, Jiangbin; Amaravadi, Ravi K.; Ignatova, Zoya; Fuchs, Serge Y.; Diehl, J. Alan; Ruggero, Davide; Koumenis, Constantinos

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2019-07

10.1038/s41556-019-0347-9

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Abstract:

Activating transcription factor 4 (ATF4) promotes MYC-driven tumour progression. Tameire et al. identify ATF4 and its target eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) as regulators of MYC-mediated amino acid biosynthesis and protein synthesis, thereby modulating tumour progression and survival in mice.