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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Liu, Xiaoguang; Olszewski, Kellen; Zhang, Yilei; Lim, Esther W.; Shi, Jiejun; Zhang, Xiaoshan; Zhang, Jie; Lee, Hyemin; Koppula, Pranavi; Lei, Guang; Zhuang, Li; You, M. James; Fang, Bingliang; Li, Wei; Metallo, Christian M.; Poyurovsky, Masha V.; Gan, Boyi

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2020-04

10.1038/s41556-020-0496-x

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Number: 4 Publisher: Nature Publishing Group

Abstract:

Liu et al. show that cancer cells with high levels of SLC7A11 have increased dependency on the pentose phosphate pathway and consequently accumulate disulfide, and can be therapeutically targeted by limiting glucose supply.