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Histidine catabolism is a major determinant of methotrexate sensitivity

Kanarek, Naama; Keys, Heather R.; Cantor, Jason R.; Lewis, Caroline A.; Chan, Sze Ham; Kunchok, Tenzin; Abu-Remaileh, Monther; Freinkman, Elizaveta; Schweitzer, Lawrence D.; Sabatini, David M.

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2018-07

10.1038/s41586-018-0316-7

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Abstract:

Histidine metabolism influences the sensitivity of cancer cells to methotrexate, with mice bearing leukaemia xenografts showing increased response to the drug upon histidine supplementation.