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Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

Loh, Po-Ru; Genovese, Giulio; Handsaker, Robert E.; Finucane, Hilary K.; Reshef, Yakir A.; Palamara, Pier Francesco; Birmann, Brenda M.; Talkowski, Michael E.; Bakhoum, Samuel F.; McCarroll, Steven A.; Price, Alkes L.

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2018-07

10.1038/s41586-018-0321-x

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Abstract:

Analysis of genotyping data for more than 150,000 individuals from the UK Biobank using long-range phase information sheds light on mechanisms of clonal haematopoiesis.