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Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Bohn, Toszka; Rapp, Steffen; Luther, Natascha; Klein, Matthias; Bruehl, Till-Julius; Kojima, Nobuhiko; Lopez, Pamela Aranda; Hahlbrock, Jennifer; Muth, Sabine; Endo, Shogo; Pektor, Stefanie; Brand, Almut; Renner, Kathrin; Popp, Vanessa; Gerlach, Katharina; Vogel, Dennis; Lueckel, Christina; Arnold-Schild, Danielle; Pouyssegur, Jacques; Kreutz, Marina; Huber, Magdalena; Koenig, Jochem; Weigmann, Benno; Probst, Hans-Christian; Stebut, Esther von; Becker, Christian; Schild, Hansjoerg; Schmitt, Edgar; Bopp, Tobias
Abstract:
Tumors can vary in both their control by immunosurveillance and their glycolytic activity. Bopp and colleagues demonstrate that highly glycolytic tumors acidify their microenvironment and use this to initiate a mechanism of localized immunosuppression.
Automatic Tags
Humans; Glycolysis; Mice; Acidosis; Mice, Inbred C57BL; Mice, Transgenic; Tumor Microenvironment; Adenocarcinoma; Colonic Neoplasms; Macrophages; Melanoma; Tumor Escape
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