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Plasma Levels of TMAO can be Increased with ‘Healthy’ and ‘Unhealthy’ Diets and Do Not Correlate with the Extent of Atherosclerosis but with Plaque Instability

Koay, Yen Chin; Chen, Yung-Chih; Wali, Jibran A.; Luk, Alison W. S.; Li, Mengbo; Doma, Hemavarni; Reimark, Rosa; Zaldivia, Maria T. K.; Habtom, Habteab T.; Frank, Ashley E.; Fusco-Allison, Gabrielle; Yang, Jean; Holmes, Andrew; Simpson, Stephen J.; Peter, Karlheinz; O’Sullivan, John F.

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10.1093/cvr/cvaa094

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Abstract:

AbstractAims. The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has attracted major interest and controversy both as a diagnostic biomarker and t