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A Scan for Human-Specific Relaxation of Negative Selection Reveals Unexpected Polymorphism in Proteasome Genes

Somel, Mehmet; Wilson Sayres, Melissa A.; Jordan, Gregory; Huerta-Sanchez, Emilia; Fumagalli, Matteo; Ferrer-Admetlla, Anna; Nielsen, Rasmus

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July 31, 2013

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10.1093/molbev/mst098

Publisher: Oxford Academic

Abstract:

Abstract. Environmental or genomic changes during evolution can relax negative selection pressure on specific loci, permitting high frequency polymorphisms at

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