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Obesity‐induced lymphatic dysfunction is reversible with weight loss
Nitti, Matthew D.; Hespe, Geoffrey E.; Kataru, Raghu P.; García Nores, Gabriela D.; Savetsky, Ira L.; Torrisi, Jeremy S.; Gardenier, Jason C.; Dannenberg, Andrew J.; Mehrara, Babak J.
Abstract:
Obesity induces lymphatic leakiness, decreases initial lymphatic vessel density, impairs collecting vessel pumping and decreases transport of macromolecules.Obesity results in perilymphatic inducible nitric oxide synthase (iNOS) expression and accumulation of T cells and macrophages.Deleterious effects of obesity on the lymphatic system correlate with weight gain.Weight loss restores lymphatic function in obese animals and decreases perilymphatic iNOS and inflammatory cell accumulation.
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