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A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance

Rossetti, Giulia; Ermer, Judith A.; Stentenbach, Maike; Siira, Stefan J.; Richman, Tara R.; Milenkovic, Dusanka; Perks, Kara L.; Hughes, Laetitia A.; Jamieson, Emma; Xiafukaiti, Gulibaikelamu; Ward, Natalie C.; Takahashi, Satoru; Gray, Nicola; Viola, Helena M.; Hool, Livia C.; Rackham, Oliver; Filipovska, Aleksandra

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2021-09

10.1126/sciadv.abi7514

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Publisher: American Association for the Advancement of Science PMID: 34559558

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Abstract:

Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Recently, a missense N437S variant was identified in the MRPP3 gene, which encodes a mitochondrial RNA processing enzyme within the RNase P complex, ...