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Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

Koval, Olha M.; Nguyen, Emily K.; Santhana, Velarchana; Fidler, Trevor P.; Sebag, Sara C.; Rasmussen, Tyler P.; Mittauer, Dylan J.; Strack, Stefan; Goswami, Prabhat C.; Abel, E. Dale; Grumbach, Isabella M.

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April 30, 2019

10.1126/scisignal.aav1439

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Abstract:

The mitochondrial Ca2+ uniporter enables ATP production to match energy demands during the cell cycle. The mitochondrial Ca2+ uniporter enables ATP production to match energy demands during the cell cycle.