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Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation

Tavakoli, Sina; Short, John D.; Downs, Kevin; Nguyen, Huynh Nga; Lai, Yanlai; Zhang, Wei; Jerabek, Paul; Goins, Beth; Sadeghi, Mehran M.; Asmis, Reto

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2017-04

10.1148/radiol.2016160839

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PMID: 27849433 PMCID: PMC5375627

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Abstract:

Despite the significant differences in the immunologic and metabolic profiles of macrophages stimulated with macrophage colony-stimulating factor (M-CSF) versus granulocyte-M-CSF, their phenotypes are not distinguishable with fluorine 18 fluorodeoxyglucose PET because of their similar level of glucose uptake.