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Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

Pello, Oscar M.; De Pizzol, Maria; Mirolo, Massimiliano; Soucek, Laura; Zammataro, Luca; Amabile, Angelo; Doni, Andrea; Nebuloni, Manuela; Swigart, Lamorna B.; Evan, Gerard I.; Mantovani, Alberto; Locati, Massimo

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January 12, 2012

10.1182/blood-2011-02-339911

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Publisher: American Society of Hematology

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Abstract:

In response to microenvironmental signals, macrophages undergo different activation, including the “classic” proinflammatory phenotype (also called M1), the “al

Automatic Tags

Female; Humans; Signal Transduction; Cells, Cultured; Blotting, Western; Breast Neoplasms; Colon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Colonic Neoplasms; Macrophages; Real-Time Polymerase Chain Reaction; Macrophage Activation; PPAR gamma; Gene Expression Regulation, Neoplastic; Proto-Oncogene Proteins c-myc; Pancreatic Neoplasms; Gene Expression Profiling; Biomarkers, Tumor; Cell Differentiation; Oligonucleotide Array Sequence Analysis; Interleukin-4; Chromatin Immunoprecipitation; STAT6 Transcription Factor