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Single-photon emission computed tomography/computed tomography imaging of RAGE in smoking-induced lung injury

Goldklang, Monica P.; Tekabe, Yared; Zelonina, Tina; Trischler, Jordis; Xiao, Rui; Stearns, Kyle; Rodriguez, Krissy; Shields, Alexander; Romanov, Alexander; D’Armiento, Jeanine M.; Johnson, Lynne L.

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June 10, 2019

10.1186/s12931-019-1064-4

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Abstract:

Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposure.