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Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma

Yang, Jianyu; Lin, Ping; Yang, Minwei; Liu, Wei; Fu, Xueliang; Liu, Dejun; Tao, Lingye; Huo, Yanmiao; Zhang, Junfeng; Hua, Rong; Zhang, Zhigang; Li, Yixue; Wang, Liwei; Xue, Jing; Li, Hong; Sun, Yongwei

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January 4, 2021

10.1186/s13059-020-02222-w

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Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers due to its high metastasis rate in the liver. However, little is known about the molecular features of hepatic metastases due to difficulty in obtaining fresh tissues and low tumor cellularity.

Automatic Tags

Genomics; Transcriptomics; Tumor microenvironment; C1q; Hepatic metastasis; Pancreatic ductal adenocarcinoma