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Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease

Phillips, Matthew C. L.; Deprez, Laura M.; Mortimer, Grace M. N.; Murtagh, Deborah K. J.; McCoy, Stacey; Mylchreest, Ruth; Gilbertson, Linda J.; Clark, Karen M.; Simpson, Patricia V.; McManus, Eileen J.; Oh, Jee-Eun; Yadavaraj, Satish; King, Vanessa M.; Pillai, Avinesh; Romero-Ferrando, Beatriz; Brinkhuis, Martijn; Copeland, Bronwyn M.; Samad, Shah; Liao, Shenyang; Schepel, Jan A. C.

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February 23, 2021

10.1186/s13195-021-00783-x

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Abstract:

Brain energy metabolism is impaired in Alzheimer’s disease (AD), which may be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine whether a 12-week modified ketogenic diet improved cognition, daily function, or quality of life in a hospital clinic of AD patients.

Automatic Tags

Ketogenic diet; Quality of life; Cognition; Alzheimer’s disease; Daily function; Randomized crossover trial