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Neuregulin 1/ErbB4 signaling contributes to the anti-epileptic effects of the ketogenic diet
Wang, Jin; Huang, Jie; Li, Yuan-Quan; Yao, Shan; Wu, Cui-Hong; Wang, Ying; Gao, Feng; Xu, Min-Dong; Huang, Guo-Bin; Zhao, Chang-Qin; Wu, Jia-Hui; Zhang, Yun-Long; Jiao, Renjie; Deng, Zi-Hao; Jie, Wei; Li, Hui-Bin; Xuan, Aiguo; Sun, Xiang-Dong
Abstract:
The ketogenic diet (KD) has been recognized as a potentially effective therapy to treat neuropsychiatric diseases, including epilepsy. Previous studies have indicated that KD treatment elevates γ-Amino butyric acid (GABA) levels in both human and murine brains, which presumably contributes to the KD’s anti-seizure effects. However, this has not been systematically investigated at the synaptic level, and the underlying molecular mechanisms remain to be elucidated.
Automatic Tags
Epilepsy; Ketogenic diet; ErbB4; GABAergic activity; Neuregulin 1
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